300 mcg Total PRMs with added EPA/DHA

Spoken’s Pro Resolving Mediators + EPA/DHA was intentionally formulated to manage pain, help our bodies
avoid the ravages of injury and promote a natural, balanced recovery process. Each capsule contains 14-HDHA,
17-HDHA, and 18-HEPE, along with their source materials, eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA). Unlike other pro resolving mediator formulations, which only include metabolites, Spoken’s Pro Resolving
Mediators + EPH/DHA provides a broader spectrum of compounds to promote a normal inflammatory response.

The Natural Inflammatory Response

Every athlete knows that the inflammatory response, which is characterized by warmth, swelling, redness, and pain,
occurs with acute injury or illness. It’s the way the body deals with trauma to tissues or foreign materials—to purge
the wounded area of cellular debris and potential pathogens. Inflammation is an integral part of healing.1 Without
appropriate inflammation, tissues would be more susceptible to infection and delayed tissue repair and remodeling.1
Similarly, the resolution of inflammation is also natural and highly active process. Without timely resolution, tissues
are at risk of prolonged immune response that can itself be damaging.

Resolution by SPM Nutrition

SPMs naturally trigger a physiological response to inflammation by signaling immune cells to initiate
tissue-repair processes.3 An absence of of SPMs results in the inflammatory process struggling to
properly resolve or “turn off”, resulting in potential tissue damage. Many of the health benefits of
omega-3 fatty acids are thought to be mediated by SPMs, and2 Supplementation of SPM-enriched
fish oils increases blood SPM concentrations.2,4 Preclinical and human studies have demonstrated
the effects of orally administered SPMs on the natural resolution of the inflammatory process.2,4,5
For instance, supplementation of 1 to 2 grams per day of SPM-enriched fish oil for 12 weeks was
shown to support joint comfort.

As an athlete, excellent nutrition is a critical aspect of maintaining performance and recovering from
injury. SPM nutrition is no exception. SPM contains a standardized level of PRMs in marine lipid
concentrate, coupled with EPA and DHA Omega-3s as natural and highly bioavailable triglycerides
by directly supplying EPA, DHA, and SPMs, along with a healthy diet that is low in sugars and
inflammatory fats, you can support your body’s ability to respond to tissue